What is Vitamin C?

Vitamins are essential nutrients needed by our bodies to function optimally. Most vitamins cannot be made by our bodies and so we need to include them in our diet. Vitamins are generally grouped by whether they are water soluble or fat soluble. Vitamin C or ascorbic acid is a water-soluble vitamin that was first isolated in 1923. While most plants and animals can make vitamin C, primates and humans can’t and therefore need it in their diet. Vitamin C is found in citrus fruits, green peppers, red peppers, strawberries, tomatoes, broccoli, Brussel sprouts, turnip, Indian gooseberry, and other leafy vegetables. There is more vitamin C in plant sources than animal sources in terms of diet.

Features of Vitamin C

Vitamin C or ascorbic acid can exist in an oxidized or reduced state, thus making it an important antioxidant in our bodies. Vitamin C is needed for a number of processes in our bodies involving protein, fat and iron metabolism. There has been a lot of research looking into the use of high doses of Vitamin C to treat everything from the common cold to cancer (1). Deficiency in Vitamin C is associated with conditions such as anemia, infections, bleeding gums, scurvy, poor wound healing, capillary hemorrhage, muscle degeneration, atherosclerotic plaques, and neurotic disturbances. The benefit of Vitamin C in being water soluble is that large doses can be taken to treat deficiencies and toxicity is rare as it is easily excreted from the body.  Reduced levels of Vitamin C is seen in cases of stress, high alcohol intake, smoking, fever, viral illnesses, antibiotic intake and pain killer intake.

Health benefits

Maintaining collagen in the body

Collagen represents one-third of the body’s protein. It constitutes protein of skin, bones, teeth, cartilage, tendons, blood vessels, heart valves, intervertebral discs, cornea, and eye lens. Vitamin C is involved in maintaining collagen in all these essential places (2, 3)

Synthesis of carnitine in muscle

Vitamin C is involved in the synthesis of carnitine (4, 5). Carnitine is required for the transport of long chain fatty acids to mitochondria for energy for cells. It may be involved in ensuring we have adequate energy levels.

Improving Liver function

Vitamin C is important in the transformation of cholesterol into bile acids in the liver (6). A deficiency can thus lead to cholesterol accumulation in the liver and gall stone formation (7, 8)


A deficiency of vitamin C can lead to scurvy. Early symptoms include weakness, feeling tired and soreness in the body. Without vitamin C for treatment, this can progress to a decreased amount of red blood cells, gum disease, changes in hair and bleeding.

Common cold

Vitamin C can prevent and provide some relief to the common cold. 1-3 g of vitamin C can prevent the common cold (9). Though there are some studies that challenge this. Larger doses seem to be more effective than smaller doses (10, 11).

Wound healing

There is some work suggesting Vitamin C may play a role in wound healing because of its connection to collagen processes (12, 13). Taking Vitamin C could improve the healing of any wounds.

Iron absorption

Vitamin C enhances the availability and absorption of iron from plant sources (14). Having vitamin C while ingesting iron can especially help vegetarians and vegans get enough iron.

Improving Fertility in men

While the precise role of vitamin C in relation to male reproduction is not as yet clear, it has been used in the management of male infertility (15). Higher amounts of vitamin C have been found in the seminal plasma of fertile men in comparison to infertile men (16, 17). The antioxidant activity of Vitamin C might protect sperm and testes from free radical damage.


Vitamin C can induce a reduction in blood lipid levels in both normal and hypercholesteremic individuals (18, 19). It may reduce the risk of developing cardiovascular disease (20, 21). Vitamin C protects against oxidative damage to LDL cholesterol through its antioxidant activity as well (22)


High doses of Vitamin C may improve the survival of patients with terminal cancer (23-25). High intake of Vitamin C is linked to low risk in certain cancers including that of the esophagus, oral cavity, stomach, pancreas, cervix, rectum, and breast (26, 27).


A higher concentration of Vitamin C in plasma has been linked with a reduced risk of diabetes (28). The specific mechanisms involved have not been identified as yet.


Vitamin C is involved in several processes involved in immunity (29). Vitamin C inhibits an overactive immune system while supporting general immune processes (30, 31). It also protects immune cells through its antioxidant activity.

Neurodegenerative disorders

There is some evidence to show that high doses of Vitamin C might improve the mental condition of schizophrenics (32). It does this through the antioxidant activity of vitamin C which protects against free radical damage in the brain. Oral supplementation with antipsychotics is a possible treatment for schizophrenia (33).


Please use the dose of vitamin C that is recommended in the label for supplements. The daily recommended amounts are 90 mg for men and 75 mg for women. Higher doses to a certain extent can be taken as it is easily excreted by the body. Doses higher than 1800 mg per day could create problems with the kidney.


Vitamin C is considered safe while following recommendations on the labels or by a doctor. In some people, vitamin C might cause nausea, vomiting, heartburn, stomach cramps, headache, and other side effects. This is especially true while taking higher doses of Vitamin C.  Higher doses to increase the risk of kidney problems including kidney stones. If you do experience any of these side effects, please stop taking vitamin C and see a doctor as necessary.

MapleLife Vitamin C

MapleLife provides high quality supplements at a fantastic reasonable price. They provide Vitamin C along with other vitamins for your daily needs. With all the benefits of vitamin C discussed in this article, it is clear that it is essential for your daily activities and overall health. If you are not eating enough fruits and vegetables to be getting enough vitamin C a day, it is highly recommended that you take Vitamin C supplements. As the excess from your body can be easily excreted, there is no harm in taking vitamin C supplements.


  1. Dunitz JD. Linus Carl Pauling. 28 February 1901–19 August 1994. Biographical Memoirs of Fellows of the Royal Society. 1996;42:316–8.
  2. May JM, Zhi-chao Q. Transport and intracellular accumulation of vitamin C in endothelial cells: relevance to collagen synthe- sis. Arch Biochem Biophys. 2005;434:178–86.
  3. Maehata Y, Takamizawa S, Ozawa S, Izukuri K, Kato Y, Sato S, et al. Type III collagen is essential for growth acceleration of human osteoblastic cells by ascorbic acid 2-phosphate, a long- acting vitamin C derivative. Matrix Biol. 2007;26(5):371–81.
  4. Hulse JD, Ellis SR, Henderson LM. Carnitine biosynthesis-beta hydroxylation of trimethyllysine by an a-ketoglutarate dependent mitochondrial dioxygenase. J Biol Chem. 1978;253:1654–9.
  5. Rebouche CJ. Ascorbic acid and carnitine biosynthesis. Am J Clin Nutr. 1991;54(6):1147S–52S.
  6. Anon. Ascorbic acid and catabolism of cholesterol. Nutr Rev 1973;31:154.
  7. Ginter E, Bobek P, Jurcovicova M. Role of ascorbic acid in lipid metabolism. In: Seith PA, Toblert BM, editors. Ascorbic acid, chemistry, metabolism and uses. Washington DC: American Chemical Society; 1982. p. 381–93.
  8. Gustafsson U, Wang FH, Axelson M, Kallner A, Sahlin S, Ei- narsson K. The effect of vitamin C in high doses on plasma and biliary lipid composition in patients with cholesterol gallstones: prolongation of the nucleation time. Eur J Clin Invest. 1997;27(5):387–91.
  9. Pauling L. Vitamin C and common cold. San Francisco: Free- man; 1970.
  10. Hemila¨ H, Chalker E. Vitamin C for preventing and treating the common cold. Cochrane Database Syst Rev. 2013;1:CD000980. doi:10.1002/14651858.CD000980.
  11. Douglas RM, Chalker EB, Treacy B. Vitamin C for preventing and treating the common cold. Cochrane Database Syst Rev. 2000;2:CD000980.
  12. Hellman L, Burns JJ. Metabolism of L-ascorbic acid-1-C14 in man. J Biol Chem. 1958;230:923–30.
  13. Jagetia GC, Rajanikant GK, Mallikarjun Rao KVN. Ascorbic acid increases healing of excision wounds of mice whole body exposed to different doses of c-radiation. Burns. 2007;33(4): 484–94.
  14. Hallberg L. Bioavailability of dietary iron in man. Annu Rev Nutr. 1981;1:123–7.
  15. Mathur V, Murdia A, Hakim AA, Suhalka ML, Shaktawat GS, Kothari LK. Male infertility and the present status of its man- agement by drugs. J Postgrad Med. 1979;25:90–6.
  16. Abasalt H, Colagar Eisa T, Marzony. Ascorbic acid in human seminal plasma: determination and its relationship to sperm quality. J Clin Biochem Nutr. 2009;45(2):144–9.
  17. Saleh RA, Agarwal A, Nada EA, Tonsy MH, Sharma RK, Meyer A, et al. Negative effects of increased sperm DNA damage in relation to seminal oxidative stress in men with idi- opathic and male factor infertility. Fertil Steril. 2003;79:1597.
  18. Vaney N, Sharma P, Pramod J, Varandami J, Kothari LK. Leucocyte ascorbic acid and blood lipids in normocholestero- lemic men receiving different amounts of vitamin C. Vitamin- ologia. 1988;4:47–8.
  19. Gaur GS, Dixit AK. Comparative study of vitamin C on serum lipid profile in healthy male and female human subjects. J Sci Res. 2012;4(3):775–81.
  20. Manson JE, Stampfer MJ, Willett WC, et al. A prospective study of vitamin C and incidence of coronary heart disease in women. Circulation. 1982;85:865–75.
  21. Knekt P, Reunanen A, Jarvinen R, Seppanen R, Heliovaara M, Aromaa A. Antioxidant vitamin intake and coronary mortality in a longitudinal population study. Am J Epidemiol. 1994;139:1180–9.
  22. Frei B. Vitamin C as an antiatherogen: mechanism of action. In: Packer L, Fuchs J, editors. Vitamin C in health and disease. New York: Marcel and Dekker Inc; 1997. p. 163–82.
  23. Cameron E, Campbell A. The orthomolecular treatment ofcancer. II. Clinical trial of high-dose ascorbic acid supplements in advanced human cancer. Chem Biol Interact. 1974;9:285–315.
  24. Cameron E, Pauling L. Supplemental ascorbate in the supportive treatment of cancer: prolongation of survival times in terminal human cancer. Proc Natl Acad Sci USA. 1976;73:3685–9.
  25. Cameron E, Pauling L. Supplemental ascorbate in the supportive treatment of cancer: re-evaluation of prolongation of survival times in terminal human cancer. Proc Natl Acad Sci USA. 1978;75:4538–42.
  26. Block G. Vitamin C and cancer prevention: the epidemiologic evidence. Am J Clin Nutr. 1991;53(1):270S–82S.
  27. Block G. Epidemiologic evidence regarding vitamin C and cancer. Am J Clin Nutr. 1991;54(6):1310S.
  28. Harding AH, Wareham NJ, Bingham SA, Khaw K, Luben R, Welch A, et al. Plasma vitamin C level, fruit and vegetable consumption, and the risk of new-onset type 2 diabetes mellitus: the European prospective investigation of cancer—Norfolk prospective study. Arch Intern Med. 2008;168(14):1493–9.
  29. Leibovitz B, Siegel BV. Ascorbic acid, neutrophil function, and the immune response. Int J Vit Nutr Res. 1978;48(2):159–64.
  30. Jeong YJ, Hong SW, Kim JH, Jin DH, Kang JS, Lee WJ, et al. Vitamin C-treated murine bone marrow-derived dendritic cells preferentially drive naı¨ve T cells into Th1 cells by increased IL- 12 secretions. Cell Immunol. 2011;266(2):192–9.
  31. Holmannova´ D, Kola´cˇkova´ M, Krejsek J. Vitamin C and its physiological role with respect to the components of the immune system. Vnitr Lek. 2012;58(10):743–9.
  32. Lucksch F. C-vitamin und schizophrenic. Wien Klin Woc- henschr. 1940;53:1009–11.
  33. Dakhale GN, Khanzode SD, Khanzode SS, Saoji A. Supple- mentation of vitamin C with atypical antipsychotics reduces oxidative stress and improves the outcome of schizophrenia. Psychopharmacology. 2005;182:494–8.